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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T22702 | CYM 50769 | Neuropeptide W | |
CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-ta... | |||
T1850 | Balicatib | AAE581 | Cysteine Protease |
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis. | |||
T16159 | Muramyl dipeptide | MDP | NOD |
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation... | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
T7566 | GRGDSPK | EMD 56574 | Others |
GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules. | |||
T7566L1 | GRGDSPK acetate | GRGDSPK acetate(111119-28-9 Free base) | Beta Amyloid |
GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption. | |||
T1971 | WAY-262611 | Wnt/beta-catenin | |
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay. | |||
T13360 | XRK3F2 | Autophagy | |
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | |||
T3S2312 | Poncirin | Isosakuranetin-7-neohesperidoside | Apoptosis , Others |
1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha... | |||
T2188 | Thonzonium Bromide | Proton pump , Antibacterial , Autophagy | |
Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl... | |||
T3S1729 | Dihydrolycorine | Others | |
1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inh... | |||
T3662 | Eleutheroside E | NF-κB | |
Eleutheroside E has anti-inflammatory effects by inhibiting NF-κB activities. Eleutheroside E significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the ... | |||
T15259 | Evatanepag | CP-533536 free acid | Prostaglandin Receptor |
Evatanepag (CP-533536 free acid) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM.CP-533536 demonstrated the ability to heal fractures when administered l... | |||
T1210 | Sodium etidronate | Didronel | Phosphatase |
Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha... | |||
T60554 | Schnurri-3 inhibitor-1 | Others | |
Schnurri-3 inhibitor-1, a potent inhibitor of schnurri-3, is an essential regulator of bone formation in adults that can be used in osteoporosis research. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in... | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
T69974 | Phenamil | ||
Phenamil is an irreversible inhibitor of amiloride-sensitive Na channels; derivative of amiloride, synergizing bone formation with BMP2 and inhibits BMP2 induced cyst-like bone formation. | |||
T26448 | A 79175 | A79175,A-79175 | |
A 79175 is a 5-lipoxygenase inhibitor that increases bone formation. | |||
T31940 | Glucosylgalactosylhydroxylysine | Hydroxylysine-glucose-galactose | |
Glucosylgalactosylhydroxylysine is a bone formation and bone resorption marker that is related to bone turnover processes during growth and development as well as metabolic bone diseases. |